https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40457 Wed 27 Jul 2022 11:14:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25928 −9) more prevalent in genomic regions that are likely to have undergone recent positive selection in humans (i.e., with a low NSS score). Variants in brain-related genes with a low NSS score confer significantly higher susceptibility than variants in other brain-related genes. The enrichment is strongest for schizophrenia, but we cannot rule out enrichment for other phenotypes. The false discovery rate conditional on the evolutionary proxy points to 27 candidate schizophrenia susceptibility loci, 12 of which are associated with schizophrenia and other psychiatric disorders or linked to brain development. Conclusions: Our results suggest that there is a polygenic overlap between schizophrenia and NSS score, a marker of human evolution, which is in line with the hypothesis that the persistence of schizophrenia is related to the evolutionary process of becoming human.]]> Wed 12 Aug 2020 09:42:59 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29038 Wed 11 Apr 2018 14:13:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22232 Wed 11 Apr 2018 13:37:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33388 Tue 03 Sep 2019 17:54:11 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33389 Tue 03 Sep 2019 17:54:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34615 Thu 04 Apr 2019 09:04:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21465 DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.]]> Sat 24 Mar 2018 07:52:31 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29641 Sat 24 Mar 2018 07:41:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29335 Sat 24 Mar 2018 07:34:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50977 Mon 14 Aug 2023 15:24:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42814 Mon 05 Sep 2022 14:06:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51931 1.5 SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.]]> Fri 22 Sep 2023 11:07:30 AEST ]]>